Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/3231
Title: TL1A MEDIATES FIBROBLAST-LIKE SYNOVIOCYTES MIGRATION AND INDIAN HEDGEHOG SIGNALING PATHWAY VIA TNFR2 IN PATIENTS WITH RHEUMATOID ARTHRITIS
Authors: Al-Azab, M.
Wei, J.
Ouyang, X.
Elkhider, A.
Walana, W.
Sun, X.
Tang, Y.
Wang, B.
Li, X.
Keywords: rheumatoid arthritis
TNF-like cytokine 1A
fibroblast-like synoviocytes
Indian hedgehog
patched1
2 receptors
TNFreceptor2
Issue Date: 2018
Publisher: Springer Nature
Series/Report no.: Vol. 29;Issue 1
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joints inflammation. One of the aggressive characteristics of RA fibroblast-like synoviocytes (FLS) is the tendency for migration in the local environment, which plays a central role in the RA pathogenesis. Tumor Necrosis Factor (TNF)-like cytokine 1A (TL1A) is a member of TNF superfamily, which has a role in autoimmunity and influences the RA-FLS behavior through TNF receptor 2 (TNFR2).We investigated the effect of TNF-like cytokine 1A (TL1A) on RA-FLS migration using patients’ samples. Specifically, we examined the hedgehog signaling pathway which is a key regulator in chondrocyte growth and differentiation. We found that TL1A increased significantly the hedgehog homologue Indian hedgehog (IHH) and its receptor Patched 1, 2 (PTCH 1, 2) in RA-FLS. In addition, TL1A-stimulated RAFLSpromoted significantlyIHHprotein expression.However, bothmRNAand protein levels decreased substantially after blocking TL1A with TNFR2 antagonist. The migratory property of RA-FLS was enhanced after stimulation of RA-FLS with TL1A, but was compromised following TL1A blockage. In conclusion, our study has revealed that TL1A modulated RA-FLS migration and Indian hedgehog signaling pathway using TNFR2.
URI: http://hdl.handle.net/123456789/3231
ISSN: 1952-4005
Appears in Collections:School of Medicine and Health Sciences



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