Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/3231
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dc.contributor.authorAl-Azab, M.-
dc.contributor.authorWei, J.-
dc.contributor.authorOuyang, X.-
dc.contributor.authorElkhider, A.-
dc.contributor.authorWalana, W.-
dc.contributor.authorSun, X.-
dc.contributor.authorTang, Y.-
dc.contributor.authorWang, B.-
dc.contributor.authorLi, X.-
dc.date.accessioned2021-10-19T10:50:54Z-
dc.date.available2021-10-19T10:50:54Z-
dc.date.issued2018-
dc.identifier.issn1952-4005-
dc.identifier.urihttp://hdl.handle.net/123456789/3231-
dc.description.abstractRheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joints inflammation. One of the aggressive characteristics of RA fibroblast-like synoviocytes (FLS) is the tendency for migration in the local environment, which plays a central role in the RA pathogenesis. Tumor Necrosis Factor (TNF)-like cytokine 1A (TL1A) is a member of TNF superfamily, which has a role in autoimmunity and influences the RA-FLS behavior through TNF receptor 2 (TNFR2).We investigated the effect of TNF-like cytokine 1A (TL1A) on RA-FLS migration using patients’ samples. Specifically, we examined the hedgehog signaling pathway which is a key regulator in chondrocyte growth and differentiation. We found that TL1A increased significantly the hedgehog homologue Indian hedgehog (IHH) and its receptor Patched 1, 2 (PTCH 1, 2) in RA-FLS. In addition, TL1A-stimulated RAFLSpromoted significantlyIHHprotein expression.However, bothmRNAand protein levels decreased substantially after blocking TL1A with TNFR2 antagonist. The migratory property of RA-FLS was enhanced after stimulation of RA-FLS with TL1A, but was compromised following TL1A blockage. In conclusion, our study has revealed that TL1A modulated RA-FLS migration and Indian hedgehog signaling pathway using TNFR2.en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofseriesVol. 29;Issue 1-
dc.subjectrheumatoid arthritisen_US
dc.subjectTNF-like cytokine 1Aen_US
dc.subjectfibroblast-like synoviocytesen_US
dc.subjectIndian hedgehogen_US
dc.subjectpatched1en_US
dc.subject2 receptorsen_US
dc.subjectTNFreceptor2en_US
dc.titleTL1A MEDIATES FIBROBLAST-LIKE SYNOVIOCYTES MIGRATION AND INDIAN HEDGEHOG SIGNALING PATHWAY VIA TNFR2 IN PATIENTS WITH RHEUMATOID ARTHRITISen_US
dc.typeArticleen_US
Appears in Collections:School of Medicine and Health Sciences



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