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http://hdl.handle.net/123456789/3231
Title: | TL1A MEDIATES FIBROBLAST-LIKE SYNOVIOCYTES MIGRATION AND INDIAN HEDGEHOG SIGNALING PATHWAY VIA TNFR2 IN PATIENTS WITH RHEUMATOID ARTHRITIS |
Authors: | Al-Azab, M. Wei, J. Ouyang, X. Elkhider, A. Walana, W. Sun, X. Tang, Y. Wang, B. Li, X. |
Keywords: | rheumatoid arthritis TNF-like cytokine 1A fibroblast-like synoviocytes Indian hedgehog patched1 2 receptors TNFreceptor2 |
Issue Date: | 2018 |
Publisher: | Springer Nature |
Series/Report no.: | Vol. 29;Issue 1 |
Abstract: | Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joints inflammation. One of the aggressive characteristics of RA fibroblast-like synoviocytes (FLS) is the tendency for migration in the local environment, which plays a central role in the RA pathogenesis. Tumor Necrosis Factor (TNF)-like cytokine 1A (TL1A) is a member of TNF superfamily, which has a role in autoimmunity and influences the RA-FLS behavior through TNF receptor 2 (TNFR2).We investigated the effect of TNF-like cytokine 1A (TL1A) on RA-FLS migration using patients’ samples. Specifically, we examined the hedgehog signaling pathway which is a key regulator in chondrocyte growth and differentiation. We found that TL1A increased significantly the hedgehog homologue Indian hedgehog (IHH) and its receptor Patched 1, 2 (PTCH 1, 2) in RA-FLS. In addition, TL1A-stimulated RAFLSpromoted significantlyIHHprotein expression.However, bothmRNAand protein levels decreased substantially after blocking TL1A with TNFR2 antagonist. The migratory property of RA-FLS was enhanced after stimulation of RA-FLS with TL1A, but was compromised following TL1A blockage. In conclusion, our study has revealed that TL1A modulated RA-FLS migration and Indian hedgehog signaling pathway using TNFR2. |
URI: | http://hdl.handle.net/123456789/3231 |
ISSN: | 1952-4005 |
Appears in Collections: | School of Medicine and Health Sciences |
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