Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/4461
Title: SERUM METABOLOME SIGNATURES CHARACTERIZING CO-INFECTION OF PLASMODIUM FALCIPARUM AND HBV IN PREGNANT WOMEN
Authors: Asantewaa, G.
Anabire, N.G.
Bauer, M.
Weis, S.
Neugebauer, S.
Quaye, O.
Helegbe, G.K.
Keywords: malaria
hepatitis B
pregnancy
serum metabolites
co-infection
Issue Date: 2023
Publisher: Multidisciplinary Digital Publishing Institute
Series/Report no.: Vol. 11;Issue: 3
Abstract: Plasmodium falciparum (P. falciparum) and hepatitis B virus (HBV) co-infection is on the rise among pregnant women in northern Ghana. Mono-infection with either of these two pathogens results in unique metabolic alterations. Thus, we aimed to explicate the effects of this co-infection on the metabolome signatures of pregnant women, which would indicate the impacted metabolic pathways and provide useful prognostic or diagnostic markers. Using an MS/MS-based targeted metabolomic approach, we determined the serum metabolome in pregnant women with P. falciparum mono-infection, HBV mono-infection, P. falciparum, and HBV co-infection and in uninfected (control) women. We observed significantly decreased sphingolipid concentrations in subjects with P. falciparum mono-infection, whereas amino acids and phospholipids were decreased in subjects with HBV monoinfection. Co-infections were found to be characterized distinctively by reduced concentrations of phospholipids and hexoses (mostly glucose) as well as altered pathways that contribute to redox homeostasis. Overall, PC ae C40:1 was found to be a good discriminatory metabolite for the coinfection group. PC ae C40:1 can further be explored for use in the diagnosis and treatment of malaria and chronic hepatitis B co-morbidity as well as to distinguish co-infections from cases of mono-infections
URI: http://hdl.handle.net/123456789/4461
ISSN: 20799721
Appears in Collections:School of Medicine and Health Sciences



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