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http://hdl.handle.net/123456789/4461
Title: | SERUM METABOLOME SIGNATURES CHARACTERIZING CO-INFECTION OF PLASMODIUM FALCIPARUM AND HBV IN PREGNANT WOMEN |
Authors: | Asantewaa, G. Anabire, N.G. Bauer, M. Weis, S. Neugebauer, S. Quaye, O. Helegbe, G.K. |
Keywords: | malaria hepatitis B pregnancy serum metabolites co-infection |
Issue Date: | 2023 |
Publisher: | Multidisciplinary Digital Publishing Institute |
Series/Report no.: | Vol. 11;Issue: 3 |
Abstract: | Plasmodium falciparum (P. falciparum) and hepatitis B virus (HBV) co-infection is on the rise among pregnant women in northern Ghana. Mono-infection with either of these two pathogens results in unique metabolic alterations. Thus, we aimed to explicate the effects of this co-infection on the metabolome signatures of pregnant women, which would indicate the impacted metabolic pathways and provide useful prognostic or diagnostic markers. Using an MS/MS-based targeted metabolomic approach, we determined the serum metabolome in pregnant women with P. falciparum mono-infection, HBV mono-infection, P. falciparum, and HBV co-infection and in uninfected (control) women. We observed significantly decreased sphingolipid concentrations in subjects with P. falciparum mono-infection, whereas amino acids and phospholipids were decreased in subjects with HBV monoinfection. Co-infections were found to be characterized distinctively by reduced concentrations of phospholipids and hexoses (mostly glucose) as well as altered pathways that contribute to redox homeostasis. Overall, PC ae C40:1 was found to be a good discriminatory metabolite for the coinfection group. PC ae C40:1 can further be explored for use in the diagnosis and treatment of malaria and chronic hepatitis B co-morbidity as well as to distinguish co-infections from cases of mono-infections |
URI: | http://hdl.handle.net/123456789/4461 |
ISSN: | 20799721 |
Appears in Collections: | School of Medicine and Health Sciences |
Files in This Item:
File | Description | Size | Format | |
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SERUM METABOLOME SIGNATURES CHARACTERIZING CO-INFECTION OF PLASMODIUM FALCIPARUM AND HBV IN PREGNANT WOMEN.pdf | 5.19 MB | Adobe PDF | View/Open |
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