Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/4101
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dc.contributor.authorOsei-Boakye, F.-
dc.contributor.authorAddai-Mensah, O.-
dc.contributor.authorOwusu, M.-
dc.contributor.authorSaasi, A.-R.-
dc.contributor.authorAppiah, S. K.-
dc.contributor.authorNkansah, C.-
dc.contributor.authorWiafe, Y. A.-
dc.contributor.authorDebrah, A. Y.-
dc.date.accessioned2023-11-20T11:32:55Z-
dc.date.available2023-11-20T11:32:55Z-
dc.date.issued2022-
dc.identifier.urihttp://hdl.handle.net/123456789/4101-
dc.description.abstractTuberculosis constitutes a global emergency as it affects one third of the world’s inhabitants. Although Pulmonary tubercu losis (PTB) is curable, immunological responses to the infection induce several hematological derangements. This study evalu ated the effect of PTB on natural anticoagulant activity and CBC indices. Ninety adults were recruited: 60 PTB patients and 30 non-TB controls. Blood specimens from each participant was tested for Proteins C and S, Antithrombin-III and CBC. Pulmonary TB was associated with significantly reduced Protein C activity (101.46 [87.61–128.3] vs 121.44 [99.50–149.8] IU/L, p= 0.038), RBC (p< 0.0001), HgB (p= 0.0019), HCT (p< 0.0001), MCV (p= 0.0133) and PDW (p< 0.0001) compared to controls. Conversely, PTB patients were associated with sig nificantly increased MCH (p= 0.0086), TWBC (p= 0.0047), Abs. GRAN (p= 0.0226), RDW-CV (p< 0.0001), MCHC (p< 0.0001) and MPV (p= 0.0027) compared to controls. The PTB patients were disproportionately affected with anemia (91.7%, p= 0.001), ery throcytopenia (75.0%, p≤ 0.001) and reduced HCT (80.0%, p≤ 0.001). The frequency of thrombocytosis, leucocytosis, and granulocytosis (50.0%, p= 0.013; 23.3%, p= 0.013; 18.3%, p= 0.025; respectively) in PTB patients were significantly higher than in controls. PTB predisposes to hypercoagulability and causes derangements in erythrocytes, leucocytes, and thrombo cytes, and disproportionately causes anemia. Measurement of Protein C activity and CBC indices are useful in the management of PTB patientsen_US
dc.language.isoenen_US
dc.relation.ispartofseriesVol.43;No. 3-
dc.subjectHematological Profileen_US
dc.subjectHypercoagulabilityen_US
dc.subjectProtein Cen_US
dc.subjectProtein Sen_US
dc.subjectPulmonary Tuberculosisen_US
dc.titleEFFECT OF PULMONARY TUBERCULOSIS ON NATURAL ANTICOAGULANT ACTIVITY IN THERAPY-NAÏVE GHANAIAN ADULTS; A CASE-CONTROL STUDYen_US
dc.typeArticleen_US
Appears in Collections:School of Allied Health Sciences



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