Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/3230
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dc.contributor.authorGamallat, Y.-
dc.contributor.authorRen, X.-
dc.contributor.authorWalana, W.-
dc.contributor.authorMeyiah, A.-
dc.contributor.authorXinxiu, R.-
dc.contributor.authorZhu, Y.-
dc.contributor.authorLi, M.-
dc.contributor.authorSong, S.-
dc.contributor.authorXie, L.-
dc.contributor.authorJamalat, Y.-
dc.contributor.authorSaleem, M. Z.-
dc.contributor.authorMa, Y.-
dc.contributor.authorXin, Y-
dc.contributor.authorShang, D.-
dc.date.accessioned2021-10-19T09:58:24Z-
dc.date.available2021-10-19T09:58:24Z-
dc.date.issued2019-
dc.identifier.issn17564646-
dc.identifier.urihttp://hdl.handle.net/123456789/3230-
dc.description.abstractLactobacillus rhamnosus (LGG) is well documented strain with wide clinical applications. We investigated herein the possible protection role of LGG in against early preneoplastic colon carcinogenesis Aberrant crypt foci (ACF) in rat model. Sprague Dawley rats were pre-treated with or without LGG via oral gavage, followed by ACF induction with Dimethylhydrazine (DMH). LGG treated groups showed significant decrease in total number of ACF’s, and increased Bax, P53, and Caspase-3 proteins expression with significant attenuation of NFkB, Cox2 and β catenin expression compared to DMH group. Serum cytokines array revealed significant elevation of IL-2, IL-6, and IFN-γ, and attenuated level of IL-10 in LGG+DMH treated animals. Finally, the 16S rRNA fecal microbiome genomic analysis showed that LGG alters the gut microbiome structure, composition and functions at phylum, family and genus level. Collectively, LGG reduces colon ACFs incidence and multiplicity via inhibition of procarcinogenesis biomarkers and modulate the gut microbiomeen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesVol. 53;-
dc.subjectAberrant crypt foci (ACF)en_US
dc.subjectProbioticsen_US
dc.subjectLactobacillus rhamnosus CGMCCen_US
dc.subjectColon canceren_US
dc.subject16S rRNA microbiome genomic sequencingen_US
dc.subjectKEGG orthologousen_US
dc.titlePROBIOTIC LACTOBACILLUS RHAMNOSUS MODULATES THE GUT MICROBIOME COMPOSITION ATTENUATES PRENEOPLASTIC COLORECTAL ABERRANT CRYPT FOCIen_US
dc.typeArticleen_US
Appears in Collections:School of Medicine and Health Sciences



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