IMPACT OF ENCAPSULATION TECHNIQUES (DRYING METHODS AND CARRIER MATERIALS) ON THE NUTRACEUTICALS RELEASE AND ABSORPTION MECHANISM OF MULBERRY LEAF

Abstract

Abstract The current study assesses the impact of encapsulation techniques (drying methods and carriers) on the release and intestinal permeability of mulberry leaf nutraceuticals. The Papadopoulou model revealed that the significant delay (p<0.5) in the release of nutraceuticals by encapsulation is mainly due to carrier material. This finding was corroborated by Hixson and Crowell's models which showed that the polymer matrix is a limiting factor of release rate. Furthermore, the efflux ratio showed that encapsulation, chiefly the carrier material led to a change in the intestinal absorption mechanism of biocompounds by shifting it from active transport to passive diffusion. Hence, sodium carboxymethyl cellulose was found to be more suitable for the control released of mulberry leaf nutraceuticals during in vitro digestion. While maltodextrin led to better apparent permeability of biocompounds. With regard to drying techniques, spray drying resulted in better control release and intestinal permeability of biocompounds than freeze drying. Novelty impact statement: The significant delay in the release of nutraceuticals by encapsulation is mainly due to carrier material. Additionally, encapsulation, chiefly encapsulating agents led to a change in the intestinal absorption mechanism of biocompounds by shifting it from active transport to passive diffusion. With regard to drying techniques, spray drying resulted in better control release and intestinal permeability of biocompounds than of freeze drying.