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DC Field | Value | Language |
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dc.contributor.author | Abdul- Mumin, A. | - |
dc.contributor.author | Abubakari, A. | - |
dc.contributor.author | Agbozo, F. | - |
dc.contributor.author | Abdul- Karim, A. | - |
dc.contributor.author | Nuertey, B. D. | - |
dc.contributor.author | Mumuni, K. | - |
dc.contributor.author | Heuschen, A. K. | - |
dc.contributor.author | Hennig, L. | - |
dc.contributor.author | Denkinger, C. M. | - |
dc.contributor.author | Muller, O. | - |
dc.contributor.author | Jahn, A. | - |
dc.date.accessioned | 2024-07-16T09:16:43Z | - |
dc.date.available | 2024-07-16T09:16:43Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 2767-3375 | - |
dc.identifier.uri | http://hdl.handle.net/123456789/4195 | - |
dc.description.abstract | The testing capacity for SARS-CoV-2 in Africa is rather limited. Antigen detection rapid diagnostic tests (Ag-RDTs) are a cheap and rapid alternative to reverse transcriptase-polymerase chain reaction (RT-PCR) tests, but there is little data about their performance under real life conditions in tropical countries. The objective of this study is to evaluate the performance of a standard Ag-RDT in a population of a major hospital in northern Ghana. Prospective, cross-sectional, blinded verification of the performance of the SD Biosensor Standard Q SARS-CoV-2 Ag-RDT under real life conditions in 135 symptomatic patients and 58 contacts of RT-PCR positives at Tamale Teaching Hospital in February 2021. Nasopharyngeal samples were taken under standard conditions and tested against RT-PCR in the hospital laboratory. 193 participants (median age 35 years, 109 male) were included into the study for which both RT-PCR test and Ag-RDT results were available. A total of 42 (22%) wereRT-PCR positive. Of the 42 RT-PCR positives, 27 were Ag-RDT positive, resulting in a sensitivity of 64% (95% CI 49–79). Sensitivity among symptomatic patients was 58% (95% CI 38–78). 123 were identified Ag-RDT negatives of the 151 RT-PCR negatives, resulting in a specificity of 81% (95% CI 75–87). SARS-CoV-2 Ag-RDTs appear to have a rather low sensitivity and particularly a low specificity under real life conditions in Africa. The role of existing Ag-RDTs in countries with high-temperature climates and limited resources still needs more data and discussion | en_US |
dc.language.iso | en | en_US |
dc.publisher | PLOS GLOBAL PUBLIC HEALTH | en_US |
dc.relation.ispartofseries | Vol. 1;Issue. 12 | - |
dc.title | FIELD EVALUATION OF SPECIFICITY AND SENSITIVITY OF A STANDARD SARS-COV-2 ANTIGEN RAPID DIAGNOSTIC TEST: A PROSPECTIVE STUDY AT A TEACHING HOSPITAL IN NORTHERN GHANA | en_US |
dc.type | Article | en_US |
Appears in Collections: | School of Medicine and Health Sciences |
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FIELD EVALUATION OF SPECIFICITY AND SENSITIVITY OF A STANDARD SARS-COV-2 ANTIGEN RAPID DIAGNOSTIC TEST A PROSPECTIVE STUDY AT A TEACHING HOSPITAL IN NORTHERN GHANA.pdf | 439.94 kB | Adobe PDF | View/Open |
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