Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/4028
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dc.contributor.authorAcquah, S. K. E.-
dc.contributor.authorAsare, P.-
dc.contributor.authorOsei-Wusua, S.-
dc.contributor.authorMorgana, P.-
dc.contributor.authorAfuma, T.-
dc.contributor.authorAsandema, D. A.-
dc.contributor.authorDansoa, E. K.-
dc.contributor.authorOtcherea, I. D.-
dc.contributor.authorOfori, L. A.-
dc.contributor.authorObiri-Dansoc, K.-
dc.contributor.authorKock, R.-
dc.contributor.authorAsante-Pokua, A.-
dc.contributor.authorYeboah-Manu, D.-
dc.date.accessioned2023-06-07T10:41:27Z-
dc.date.available2023-06-07T10:41:27Z-
dc.date.issued2021-
dc.identifier.issn1201-9712-
dc.identifier.urihttp://hdl.handle.net/123456789/4028-
dc.description.abstractObjective: We conducted a cross-sectional study in the five administrative regions of Northern Ghana to determine the diversity of Mycobacterium tuberculosis complex (MTBC) sub/lineages and their susceptibility to isoniazid (INH) and rifampicin (RIF). Methods: Sputum specimens were collected and cultured from 566 pulmonary tuberculosis patients reporting to 17 health facilities from 2015 to 2019. Mycobacterial isolates obtained from solid cultures were confirmed as members of the MTBC by PCR amplification of IS6110 and rpoß and assigned lineages and sub-lineages using spoligotyping. Results: Of 294 mycobacterial isolates recovered, MTBC species identified were: M. tuberculosis sensu stricto (Mtbss) 241 (82.0%), M. africanum 41 (13.9%) and M. bovis four (1.4%) with eight (2.7%) unidentified. The human-adapted lineages (L) identified (N=279) were L1 (8/279, 2.9%), L2 (15/279, 5.4%), L3 (7/279, 2.5%), L4 (208/279, 74.5%), L5 (13/279, 4.7%) and L6 (28/279, 10.0%) with three unidentified lineages. Among the 208 L4, the dominant sub-lineages in the region were the Cameroon 120/208 (57.7%) and Ghana 50/208 (24.0%). We found 4.4% (13/294) and 0.7% (2/294) of the patients infected with MTBC isolates resistant to INH only and RIF only, respectively, with 2.4% (7/294) being infected with MDR strains. Whereas L6 was associated with the elderly, we identified that the Ghana sub-lineage of L4 was associated with both INH and MDR (p<0.05), making them important TB pathogens in Northern Ghana and a growing public health concern.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesVol. 109;-
dc.subjectTuberculosisen_US
dc.subjectMultidrug resistanceen_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectMycobacterium africanumen_US
dc.subjectSpoligotypingen_US
dc.subjectNorthern Ghanaen_US
dc.titleMOLECULAR EPIDEMIOLOGY AND DRUG SUSCEPTIBILITY PROFILES OF MYCOBACTERIUM TUBERCULOSIS COMPLEX ISOLATES FROM NORTHERN GHANAen_US
dc.typeArticleen_US
Appears in Collections:School of Medicine and Health Sciences



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