Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/3503
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dc.contributor.authorLi, X.-
dc.contributor.authorZhang, Y.-
dc.contributor.authorWalana, W.-
dc.contributor.authorZhao, F.-
dc.contributor.authorLi, F.-
dc.contributor.authorLuo, F.-
dc.date.accessioned2022-03-25T15:30:22Z-
dc.date.available2022-03-25T15:30:22Z-
dc.date.issued2020-
dc.identifier.issn1479-6694-
dc.identifier.urihttp://hdl.handle.net/123456789/3503-
dc.description.abstractAim: Herein is presented the combined effect of PI3K inhibitor (GDC-0941) and CXCR1/2 analogue (G31P) in breast cancer. Materials & methods: Breast cancer cell lines and xenograft model were employed to test the efficacy of the combination therapy. Results: GDC-0941+G31P treatment substantially inhibited multi- plication of all the breast cancer cell lines used in this study (BT474, HCC1954 and 4T1). Even though single therapies caused a meaningful S-phase cell cycle arrest, the inhibition effect was more potent with the combined treatment. Similarly, enhanced apoptosis accompanied GDC-0941+G31P treatment. Further- more, the migration ability of the breast cancer cell lines were significantly curtailed by the combination therapy compared with the single treatments. Conclusion: The findings suggest that combination treat- ment involving PI3K inhibitor and CXCR1/2 analogue (G31P) could be a potent therapeutic option for breast cancer treatment.en_US
dc.language.isoenen_US
dc.publisherFuture Science Groupen_US
dc.relation.ispartofseriesVol.16;Issue 14-
dc.subjectbreast canceren_US
dc.subjectcancer immunologyen_US
dc.subjectcell cycleen_US
dc.subjectcombination therapyen_US
dc.subjectCXCR1/2en_US
dc.subjectG31Pen_US
dc.subjectGDC-0941en_US
dc.subjectmetastasisen_US
dc.subjectPI3Ken_US
dc.subjectproliferationen_US
dc.titleGDC-0941 AND CXCL8 (3-72) K11R/G31P COMBINATION THERAPY CONFERS ENHANCED EFFICACY AGAINST BREAST CANCERen_US
dc.typeArticleen_US
Appears in Collections:School of Medicine and Health Sciences



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