Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/3456
Title: PURIFICATION, CHARACTERIZATION, AND ANTITUMOR ACTIVITY OF A NOVEL GLUCAN FROM THE FRUITING BODIES OF CORIOLUS VERSICOLOR
Authors: Awadasseid, A.
Hou, J.
Gamallat, Y.
Xueqi, S.
Kuugbee, D. E.
Musa Hago, A.
Bamba, D.
Meyiah, A.
Chiwala, G.
Xin, Y.
Issue Date: 2017
Publisher: Public Library of Science
Series/Report no.: Vol.12;Issue 2
Abstract: Cancer is one of the most common causes of deaths worldwide. Herein, we report an efficient natural anticancer glucan (CVG) extracted from Coriolus Versicolar (CV). CVG was extracted by the hot water extraction method followed by ethanol precipitation and purified using gas exclusion chromatography. Structural analysis revealed that CVG has a linear α- glucan chain composed of only (1!6)-α-D-Glcp. The antitumor activity of CVG on Sarcoma- 180 cells was investigated in vitro and in vivo. Mice were treated with three doses of CVG (40, 100, 200 mg/kg body weight) for 9 days. Tumor weight, relative spleen, thymus weight, and lymphocyte proliferation were studied. A significant increase (P< 0.01) in relative spleen and thymus weight and a decrease (P< 0.01) in tumor weight at the doses of 100 and 200 mg/kg were observed. The results obtained demonstrate CVG has antitumor activity towards Sarcoma-180 cells by its immunomodulation activity.
URI: http://hdl.handle.net/123456789/3456
ISSN: 1932-6203
Appears in Collections:School of Medicine and Health Sciences



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