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DC Field | Value | Language |
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dc.contributor.author | Oseni, L. A. | - |
dc.contributor.author | Amiteye, D. | - |
dc.contributor.author | Antwi, S. | - |
dc.contributor.author | Tandoh, M. | - |
dc.contributor.author | Aryitey, G. M. | - |
dc.date.accessioned | 2015-12-01T11:59:31Z | - |
dc.date.available | 2015-12-01T11:59:31Z | - |
dc.date.issued | 2013-02-05 | - |
dc.identifier.issn | 2231-3354 | - |
dc.identifier.uri | http://hdl.handle.net/123456789/324 | - |
dc.description | an article from a lecturer of the department of chemistry | en_US |
dc.description.abstract | Medicinal plants represent potential sources for the discovery of new anti-inflammatory agents. Aqueous and ethanolic whole plant extracts of Phyllanthus fraternus were evaluated in vivo for their anti-inflammatory activities on carrageenan-induced paw oedema in Sprague-Dawley rats. The extracts were also screened for phytochemicals. Some of the phytochemicals found in the extracts have previously been implicated as anti-inflammatory agents. The LD50 of both extracts was investigated and found to be greater than 5000mg/kg. The extracts at doses 100mg/kg and 200mg/kg showed modest anti-inflammatory activity in a dose dependent manner. The aqueous extract demonstrated better inhibition of paw oedema compared with the ethanolic extract at 200mg/kg after 4hrs. The activity of the standard drug, indomethacin at 25.0 mg/kg was significantly higher (p< 0.05) than those of the extracts. The results suggest that whole plant extract of P. fraternus possess anti-inflammatory activity and will be useful in the search for novel anti-inflammatory agents. | en_US |
dc.language.iso | en | en_US |
dc.subject | In vivo anti-inflammatory, Phyllanthus fraternus, phytochemicals, paw oedema inhibition,Sprague-Dawley rats. | en_US |
dc.title | PRELIMINARY IN VIVO EVALUATION OF ANTI-INFLAMMATORY ACTIVITIES OF AQUEOUS AND ETHANOLIC WHOLE PLANT EXTRACTS OF PHYLLANTUS FRATERNUS ON CARRAGEENAN-INDUCED PAW OEDEMA IN SPRAGUE-DAWLEY RATS | en_US |
dc.type | Article | en_US |
Appears in Collections: | Faculty of Applied Sciences |
Files in This Item:
File | Description | Size | Format | |
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15.anti-inflammatory.pdf | article- pdf | 113.9 kB | Adobe PDF | View/Open |
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