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http://hdl.handle.net/123456789/3231
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DC Field | Value | Language |
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dc.contributor.author | Al-Azab, M. | - |
dc.contributor.author | Wei, J. | - |
dc.contributor.author | Ouyang, X. | - |
dc.contributor.author | Elkhider, A. | - |
dc.contributor.author | Walana, W. | - |
dc.contributor.author | Sun, X. | - |
dc.contributor.author | Tang, Y. | - |
dc.contributor.author | Wang, B. | - |
dc.contributor.author | Li, X. | - |
dc.date.accessioned | 2021-10-19T10:50:54Z | - |
dc.date.available | 2021-10-19T10:50:54Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1952-4005 | - |
dc.identifier.uri | http://hdl.handle.net/123456789/3231 | - |
dc.description.abstract | Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joints inflammation. One of the aggressive characteristics of RA fibroblast-like synoviocytes (FLS) is the tendency for migration in the local environment, which plays a central role in the RA pathogenesis. Tumor Necrosis Factor (TNF)-like cytokine 1A (TL1A) is a member of TNF superfamily, which has a role in autoimmunity and influences the RA-FLS behavior through TNF receptor 2 (TNFR2).We investigated the effect of TNF-like cytokine 1A (TL1A) on RA-FLS migration using patients’ samples. Specifically, we examined the hedgehog signaling pathway which is a key regulator in chondrocyte growth and differentiation. We found that TL1A increased significantly the hedgehog homologue Indian hedgehog (IHH) and its receptor Patched 1, 2 (PTCH 1, 2) in RA-FLS. In addition, TL1A-stimulated RAFLSpromoted significantlyIHHprotein expression.However, bothmRNAand protein levels decreased substantially after blocking TL1A with TNFR2 antagonist. The migratory property of RA-FLS was enhanced after stimulation of RA-FLS with TL1A, but was compromised following TL1A blockage. In conclusion, our study has revealed that TL1A modulated RA-FLS migration and Indian hedgehog signaling pathway using TNFR2. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer Nature | en_US |
dc.relation.ispartofseries | Vol. 29;Issue 1 | - |
dc.subject | rheumatoid arthritis | en_US |
dc.subject | TNF-like cytokine 1A | en_US |
dc.subject | fibroblast-like synoviocytes | en_US |
dc.subject | Indian hedgehog | en_US |
dc.subject | patched1 | en_US |
dc.subject | 2 receptors | en_US |
dc.subject | TNFreceptor2 | en_US |
dc.title | TL1A MEDIATES FIBROBLAST-LIKE SYNOVIOCYTES MIGRATION AND INDIAN HEDGEHOG SIGNALING PATHWAY VIA TNFR2 IN PATIENTS WITH RHEUMATOID ARTHRITIS | en_US |
dc.type | Article | en_US |
Appears in Collections: | School of Medicine and Health Sciences |
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TL1A MEDIATES FIBROBLAST-LIKE SYNOVIOCYTES MIGRATION AND INDIAN HEDGEHOG SIGNALING PATHWAY VIA TNFR2 IN PATIENTS WITH RHEUMATOID ARTHRITIS.pdf | 884.89 kB | Adobe PDF | View/Open |
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