Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1256
Title: NONPARAMETRIC STEPWISE PROCEDURE FOR IDENTIFICATION OF MAXIMUM SAFE DOSE (MSD)
Authors: Adjabui, M. J.
Howard, N. K.
Luguterah, A.
Keywords: Maximum safe dose
partitioning principle
Distribution-free endpoint
Familywise error rate
Issue Date: 2017
Publisher: SCIENCEDOMAIN International
Series/Report no.: Vol. 6;Issue 3
Abstract: In this article we consider identification of maximum safe dose (MSD) in a dose response study for distribution-free endpoints. Where the maximum safe dose is the highest dose level that does not exceed the median toxicity of the zero dose by a predetermined margin. A nonparametric confidence set-based approach was proposed, that is we incorporate Mann-Whitney method with the partitioning principle in a step-down fashion for safety evaluation. A comprehensive study of the familywise error rate for our new procedure was compared with the dose response (DR) procedure via a Monte Carlo simulations. An example from preclinical trial in genetic toxicology was used for illustrative purpose.
URI: http://hdl.handle.net/123456789/1256
ISSN: 2456-477X
Appears in Collections:Faculty of Mathematical Sciences

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