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http://hdl.handle.net/123456789/1256| Title: | NONPARAMETRIC STEPWISE PROCEDURE FOR IDENTIFICATION OF MAXIMUM SAFE DOSE (MSD) |
| Authors: | Adjabui, M. J. Howard, N. K. Luguterah, A. |
| Keywords: | Maximum safe dose partitioning principle Distribution-free endpoint Familywise error rate |
| Issue Date: | 2017 |
| Publisher: | SCIENCEDOMAIN International |
| Series/Report no.: | Vol. 6;Issue 3 |
| Abstract: | In this article we consider identification of maximum safe dose (MSD) in a dose response study for distribution-free endpoints. Where the maximum safe dose is the highest dose level that does not exceed the median toxicity of the zero dose by a predetermined margin. A nonparametric confidence set-based approach was proposed, that is we incorporate Mann-Whitney method with the partitioning principle in a step-down fashion for safety evaluation. A comprehensive study of the familywise error rate for our new procedure was compared with the dose response (DR) procedure via a Monte Carlo simulations. An example from preclinical trial in genetic toxicology was used for illustrative purpose. |
| URI: | http://hdl.handle.net/123456789/1256 |
| ISSN: | 2456-477X |
| Appears in Collections: | Faculty of Mathematical Sciences |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| NONPARAMETRIC STEPWISE PROCEDURE FOR IDENTIFICATION OF MAXIMUM SAFE DOSE (MSD).pdf | 305.82 kB | Adobe PDF | View/Open |
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